Home Chemistry Heterocyclic Building Blocks Pyrrolidines 2,8-Diazaspiro[4.5]Decan-3-One
Nucleophilic Addition: The carbonyl group (C=O) in the spiroindoline can undergo nucleophilic addition reactions with strong nucleophiles, such as Grignard reagents, amines, or hydrazines. This can lead to the formation of various derivatives.
Acid-Catalyzed Hydrolysis: Spiroindoline can be hydrolyzed under acidic conditions, breaking the amide bond and generating the corresponding carboxylic acid and amine.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Cyclization: Spiroindolines can undergo intramolecular reactions to form cyclic compounds, depending on the conditions and reagents used.
Alkylation: The nitrogen atoms in the spiroindoline structure can be alkylated with alkyl halides or other alkylating agents.
Oxidation: Spiroindoline can be oxidized under certain conditions to generate compounds with higher oxidation states.
Amide Formation: It can react with acid chlorides or anhydrides to form amides.
Ring-Opening Reactions: Ring-opening reactions can occur under specific conditions, leading to the formation of linear compounds.
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tert-Butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
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2,8-Diazaspiro[4.5]decan-3-one hydrochloride
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2-Ethyl-2,8-diazaspiro[4.5]decan-3-one
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2-Isopropyl-2,8-diazaspiro[4.5]decan-3-one
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2,8-Diazaspiro[4.5]decan-3-one dihydrochloride
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